Cobalamin Analogues

The massive B12 molecule is very vulnerable to being separated and having some of its component parts modified in a variety of ways. In such cases, it ceases to be a cobalamin and is no longer a vitamin useful or active for humans. However, it may remain a corrinoid (as a cobalamin analogue) for one or more of a wide variety of simpler life forms, such as algae and bacteria.[4] Intestinal bacteria synthesize, bind, and transport corrinoids (Cbl and Cbl analogues).[26],[27] Bacteria are also the prime modifiers of Cbl in the gut and have been shown to remove the lower ligand from 80% of consumed B12 for use as microbial cofactors (vitamins for bacteria), replacing it with a wide range of alternate lower ligands and forming cobalamin analogues.[26],[27]

When the finely tuned physiologic mechanisms for B12 absorption, transport, and utilization are overwhelmed with mega doses of B12, excessive analogue production takes place.[27] Because the majority of cobalamin analogues are much smaller than cobalamin, if large volumes are synthesized, they can passively diffuse into the bloodstream in amounts that could disrupt normal cellular metabolism. When intestinal bacteria are increased due to overgrowth or inflammatory conditions, there is an even greater capacity for GI analogue production and the risks that follow. Any resulting interposition of analogues in the place of Cbl can interrupt fundamental enzymatic processes necessary for normal neurologic function, DNA synthesis, and red blood cell production.

IF has been shown to physically protect B12 and prevent its uptake and modification by gut bacteria, thereby reducing cobalamin analogue synthesis and transport.[24] Thus, IF is not only the critical protein transporter in the GI tract for shepherding normal daily B12 intake amounts (4-7ug) to its dedicated receptor, but it also serves to limit and/or prevent Cbl analogue production, binding, and transport within the body’s normal B12 absorption pathway.

A comprehensive White Paper reviewing the potential risks to the body from mega dose B12 exposure is available under confidential disclosure.