What can be delivered using IF-B12-conjugates need not be confined to small molecules, small proteins or small imaging agents like PET tracers (<500 Daltons), but can be demonstrated to work with proteins as large of the tetanus vaccine component Tetanospasmin, a 150 kDa protein.
A very small unit of mass, about the mass of a hydrogen atom. Presently taken as an alternative name for the unified atomic mass unit, that is, one-twelfth of the mass of a carbon-12 atom, about 1.660538 86 × 10⁻²⁷ kilogram. Symbol, Da. It is named for the English physical chemist John Dalton (1766 – 1844), who in 1803 proposed the modern idea of the atom (though he didn't call it that) and molecule
Prof. Robert Doyle is a medicinal chemist with an interest in pharmaceutical drug and probe development for the study and treatment of obesity and type 2 diabetes. He has a broad background in peptide and protein design and expression, synthetic bio-conjugate chemistry, drug delivery, protein biochemistry and assay development. In 2005, he was appointed Assistant Professor of Chemistry at Syracuse University and promoted, with tenure, to Associate Professor in 2009 and then full Professor in 2014. He is also adjunct Associate Professor of Medicine at SUNY, Upstate Medical University (UMU). In 2016, He was named the Laura J. and L. Douglas Meredith Professor, Syracuse University. As a Principal Investigator (PI), he has focused on the chemistry of vitamin B12 and its dietary pathway and components to modify drug pharmacodynamics and/or pharmacokinetics. He has been funded by the NIH and DoD, as well as multiple societies, foundations and pharmaceutical companies. He has published over 100 research papers (35+ in the vitamin B12 space) and is the holder of over a dozen patents.
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